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购买数量：
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DESCRIPTION
Source： E. coliderived
Accession： P05231
Description : Synthetic DNA fragment encoding whole human interleukin-6 (Accession number UniProtKB P05231, IL6_HUMAN) with 6His-tag on C-terminus was used for protein expression
Predicted Molecular Mass 20.9 kDa
Presentation: 20mM Tris-HCI，PH8.0
SPECIFICATIONS
SDS- PAGE 20.9 kDa, reducing conditions.
Activity reaction with monoclonal antibodies specific to human IL6
Purity ≥ 90%
Concentration 1.7 mg/mL
Endotoxin Level <0.10 EU per 1 μg of the protein by the LAL method.
PREPARATION AND STORAGE
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it
immediately at the temperature recommended below.
Stability & Storage： 12 months from date of receipt, -20 to -80 °C as supplied.
3 months, 2 to 8 °C under sterile conditions
Application: Used as Calibrator in immunoassay，can be used as immune or screening antigens.
BACKGROUND
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.
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