DESCRIPTION Source: E. coliderived Accession: P01258 Description Recombinant Human PCT (C-6His) is produced by Mammalian expression system
and the target gene encoding Ala26-Asn141 is expressed with no tag at the
C-terminus or N-terminus Predicted Molecular Mass 13.8 kDa
SPECIFICATIONS SDS- PAGE 13.8kDa, reducing conditions. Activity reaction with monoclonal antibodies specific to human PCT Purity ≥ 90% Presentation 20mM Tris-HCI,150mM NaCI, PH8.0 Endotoxin Level <0.10 EU per 1 μg of the protein by the LAL method.
PREPARATION AND STORAGE Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it
immediately at the temperature recommended below.
Stability & Storage: 12 months from date of receipt, -20 to -80 °C as supplied.
3 months, 2 to 8 °C under sterile conditions
Application: Used as Calibrator in immunoassay,can be used as immune or screening antigens.
BACKGROUND
Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32- amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bone
References
1.Assicot M, et al. (1993) High serum procalcitonin con¬centrations in patients with sepsis and infection. Lancet 341(8844), 515-518.
2.Linscheid P, et al. (2003) In vitro and in vivo calcitonin I gene expression in parenchymal cells: A novel product of human adipose tissue. Endocrinology 144, 5578-5584.
3.Simon L, et al. (2004) Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A system¬atic review and meta-analysis. Clin. Infect. Dis. 39, 206-217.
4.Sponholz C, et al. (2006) Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Critical Care 10, R145.
5.Meisner M and Reinhart K (2001) Is procalcitonin really a marker of sepsis? Int J Intensive Care 8(1), 15-25.